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Solid Biosciences

Senior Associate Scientist, Upstream Process Development

306 - Process Development – Cambridge, Massachusetts
Department 306 - Process Development
Employment Type Full-Time
Minimum Experience Mid-level


Solid Biosciences is seeking an Associate Scientist to join our Manufacturing and Process Development team and contribute to the development of our upstream Phase III and commercial viral vector manufacturing process. This individual will join a dynamic and motivated team to develop and characterize unit operations in support of a mid to late stage viral vector program, as well as tech transfer of the process to the clinical/commercial manufacturing team. The successful candidate will support experiments supporting development, characterization, scale-up, and transfer of the upstream manufacturing processes. They will also be responsible for evaluation and implementation of new and existing technology. 

Key Duties & Accountabilities:

  • Work with supervisor to design, plan and conduct cell culture experiments using high throughput cell culture models, benchtop bioreactors and/or pilot scale Single Use Bioreactors
  • Daily monitoring and maintenance of cultures and bioreactor processes, including sampling and performing basic assays
  • Perform data analysis, prepare technical reports, SOPs, internal and external presentations
  • Coordinate with other departments and outside vendors for repair, maintenance, and/or calibration of laboratory equipment and systems
  • Ordering, stocking, and organization of lab supplies
  • Preparation of reagents, media/buffer, and equipment as needed to support experiments
  • Maintain good communication and collaboration with colleagues
  • Performs other related duties and ad hoc projects as required by position

Competencies Required:

  • Excellent communication, technical and organizational skills are required
  • Must be a team player prepared to lead, work in, and embrace a team-based culture
  • Proven troubleshooting, technical writing, problem solving and investigational skills

Knowledge: Education, Experience, & Skills:

  • Bachelor’s or Master’s degree in Chemical Engineering, Biochemical Engineering, Biochemistry or related fields with 2+ years relevant industrial experience required
  • Experience with bioreactor systems of various scales including shake flasks, spin tubes, spinners, and benchtop, WAVE bioreactors, and Single-Use pilot scale bioreactors
  • Experience using automated high-throughput and benchtop bioreactor systems
  • Experience with cell culture technologies and operations
  • Knowledge of the principles and concepts around bioreactor scale-up
  • Solid understanding and application of scientific and technical knowledge in mammalian cell culture processes
  • The candidate should be self-motivated, accountable, inquisitive, and have excellent organization and communication skills

Travel Commitment:

  • Minimal travel required
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  • Location
    Cambridge, Massachusetts
  • Department
    306 - Process Development
  • Employment Type
  • Minimum Experience
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